Ub-POD applied to the ubiquitin ligase RAD18 enables visualization of UV-induced DNA damage repair hotspots in human cells. Credit: Urbi Mukhopadhyay/EMBL, Isabel Romero Calvo/EMBL Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a critical type of protein modification process called ubiquitination. Ubiquitination plays an integral role in diverse cellular functions, and its dysregulation contributes to many human diseases, including neurodegeneration and cancer. During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a…
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Like water and oil, it’s a rare character that is fun to watch, though we avoid their personality types, like a port-a-potty on a grueling summer day. No one wants to shake hands and drink with these fictional manifestations of all the worst characteristics. But visually indulging in their underhanded dealings and delightful sadism is just too entertaining to turn away. Why rage, seething hatred, and ominous discomfort attract us time and time again is worth its own article. Civilized society has its caveats, after all. (Courtesy of Ollie Upton/HBO) Perhaps a Joffrey Baratheon lurks within the dark recesses of…
Osgood Perkins, James Wan, and Stephen King are partnering on a single film. Would a “dream team” of horror greats technically be considered a nightmare team?Whatever you want to call them, that’s the trio coming together for The Monkey. The film is based on one of Stephen King’s most famous short stories, which was originally published in 1980 and then served as the inspiration for the cover art on King’s 1985 short story collection Skeleton Crew.The film adaptation is written for the screen and directed by Osgood Perkins, who is currently riding high thanks to his surprise horror blockbuster Longlegs. And the movie is…
Billie Eilish earns her first No. 1 on both the Billboard Global 200 and Billboard Global Excl. U.S. charts as “Birds of a Feather” rises from the runner-up spot to perch atop each survey. Eilish also debuts in the top five of each chart as Charli xcx’s “Guess,” on which she’s featured, starts at No. 3 on the Global 200 and No. 5 on Global Excl. U.S. The Global 200 and Global Excl. U.S. charts, which began in September 2020, rank songs based on streaming and sales activity culled from more than 200 territories around the world, as compiled by…
While each product featured is independently selected by our editors, we may include paid promotion. If you buy something through our links, we may earn commission. Read more about our Product Review Guidelines here.You’ve probably already caught “The Kardashians” clip of Scott Disick recognizing Kim Kardashian’s Skims nipple bra on Khloé and immediately inquiring, “Do you have the new nipple bra on?” “Of course,” Khloé replies. “These are Kim’s nipples on my body.” Naturally, I adopted that very same phrase when I headed out the door with my partner for brunch wearing the one and only Skims Ultimate Nipple Push-Up…
Microsoft shut down Hi-Fi Rush developer Tango Gameworks, alongside a few other Bethesda-owned studios, in May to shift focus on to its “priority games.” Tango had at the time confirmed its closure, but the Japanese studio has now been acquired by Krafton and will remain open. The South Korean publisher announced Monday that it had integrated Tango Gameworks into its team, marking its “first significant investment in the Japanese video game market.” The deal also includes the intellectual property rights to Hi-Fi Rush, the acclaimed rhythm-based action game from Tango.Tango Gameworks Acquired by KraftonKrafton did not reveal any financial details…
It seems every other movie these days is adapted from a book, from Colleen Hoover’s highly-anticipated It Ends With Us to the latest in The Hunger Games franchise. Because they offer a rich and intricate world for filmmakers to explore, books and novels have always made excellent sources for film adaptations. And while hundreds of books have been adapted for motion pictures, some authors have achieved greater success than others. In honor of Book Lovers Day (August 9), a team of experts at WordFinderX analyzed the critical and box office performance of 473 authors and 10,164 adaptations to uncover which…
A tiny seed is stuck between loose gravel and coarse sand. There is nothing else alive around it. All it can see is a wall of ice reaching 20 metres up into the sky. It is cold. Survival is hard around here. In winter, it is dark even during the day. In summer, the sun bakes the ground hard and dry for 24 hours.The seed was left here by tourists several years ago, who came to see the wonders of the last remaining wilderness on planet Earth: Antarctica.Life is changing. Warmer temperatures are melting the glaciers and the meltwater allows…
[Warning: The below contains MAJOR spoilers for Orphan Black: Echoes Season 1 Episode 8 “The Paradox of Joyce.”] Trust doesn’t play into a key decision Eleanor (Rya Kihlstedt) makes for her future—as well as that of the younger printouts of herself—in the latest Orphan Black: Echoes. When Eleanor fills the youngest printout, Jules (Amanda Fix), in on her life, including the fact that she dies of early Alzheimer’s—which is why Kira (Keeley Hawes) made new versions of her wife—the teen asks if she can do anything, considering how brilliant she is and her discoveries in neurobiology. But the drug that Eleanor…
Tom Hardy returns in Venom: Let There Be Carnage as the lethal protector Venom, one of Marvel’s greatest and most complex characters. In search of his next big story, journalist Eddie Brock lands an exclusive interview with convicted murderer and death row inmate Cletus Kasady (played by Woody Harrelson), who discovers Eddie’s secret and becomes the host for Carnage, a menacing and terrifying symbiote. Now, Eddie and Venom must get past their contentious relationship to defeat him. Venom: Let There Be Carnage was directed by Andy Serkis (Mowgli: Legend of the Jungle, The Lord of the Rings trilogy, Dawn of…
Red Hot Chili Peppers tore through and rendition of their classic song “Can’t Stop” as part of the 2024 Olympics closing ceremony .The legendary funk rockers were part of the customary handover portion of the event, when the closing games symbolically passes the spotlight to the next host city. In this case Paris, who hosted the 2024 games, ceded the spotlight to Los Angeles, which will host the 2028 Summer Olympics.The process started with R&B sensation H.E.R. delivering an emphatic rendition of “The Star Spangled Banner” onstage in Paris. This was followed by an appearance by Hollywood star Tom Cruise,…
If there is one haircut that has dominated the past couple of years, it’s the bob haircut. Short hairstyles from the blunt bob to the Italian bob have been trending for a while, and many of us on the Who What Wear UK team have traded in our longer lengths for a chin-skimming haircut. I’ve been thinking about switching up my long hairstyle for a while, but I’ll be honest, going for a bob haircut feels a little out of my comfort zone. Which is why I’m considering a collarbone length bob haircut instead. I spoke to hairstylist Sam Burnett,…
Moms are people, too. They love their kids but also have plenty of their own hobbies (cooking! running! gaming!), and they deserve gifts that honor them as people, not just as parents. Gifts for Mom shouldn’t be about giving her a vacuum or anything related to the stereotypical cleaning tasks of parenthood—a perfect gift for your mom will show you know how she likes to spend the rest of her hours in a day when she isn’t parenting.This guide has the best gift ideas around for all kinds of moms and the activities they might love, whether it’s a holiday…
Main / Books / The Midnight Feast Book review, full book summary and synopsis for The Midnight Feast by Lucy Foley, an atmospheric slow-burn mystery about the opening weekend of a luxury coastal resort that ends in fire and death.SynopsisThe Midnight Feast by Lucy Foley opens on the weekend of the grand opening of The Manor, a luxury resort-hotel located near a dense ancient forest on the Dorset coast. Everything has been planned to perfection by its owner Francesca Meadows, a former local resident who has returned to develop this property she recently inherited, to ensure a tranquil…
Illustration of a tidal disruption eventMark Garlick/Science Photo Library/Getty Images Astronomers have caught a supermassive black hole eating a giant star in the biggest and brightest example of this powerful event ever seen. It could be the missing link that helps us understand mysteriously bright cosmic objects in the centres of some active galaxies. When a black hole gobbles up a star, it doesn’t happen in one titanic gulp – instead, the star is torn apart in a violent process called a tidal disruption event (TDE). These are some of the brightest events in the sky. Edo Berger… View Original…
Critic’s Rating: 4 / 5.04SEAL Team is back, but it’s not the same. The events of SEAL Team Season 6 set up the changes when Clay died, and Jason spat in command’s face when he received a special commendation. Jason’s actions alone would have had consequences, but when the others stood beside him, airing their dirty laundry about being debilitated by injuries sustained on the job, the whole unit came under fire. (Michael Moriatis/Paramount+) As much as I hate the idea that any TV show is “like a movie in long form” or whatnot, SEAL Team has always had incredibly…
Borderlands review – rage-quit worthy video game slop About Little White Lies Little White Lies was established in 2005 as a bi-monthly print magazine committed to championing great movies and the talented people who make them. Combining cutting-edge design, illustration and journalism, we’ve been described as being “at the vanguard of the independent publishing movement.” Our reviews feature a unique tripartite ranking system that captures the different aspects of the movie-going experience. We believe in Truth & Movies. Editorial Design View Original Source Here
Celine Dion has denounced the use of her song “My Heart Will Go On” by Donald Trump during a president campaign rally in Montana on Friday night. “In no way is this use authorized and Celine Dion does not endorse this or any similar use,” noted a statement released on Saturday. Dion concluded her statement by questioning the wisdom of the song choice, given that it famously soundtracks James Cameron’s Titanic, a movie about a sinking ship. “…And really, THAT song?” she remarked. Perhaps Trump is resigned to his fate in a head-to-head matchup against Kamala Harris. Last month, Dion…
While each product featured is independently selected by our editors, we may include paid promotion. If you buy something through our links, we may earn commission. Read more about our Product Review Guidelines here.A good pair of penny loafers are a closet staple. You can wear them from winter to summer, and from work to dinner with friends. But finding the right pair of loafers can be a challenge. Some are too stiff for everyday wear, others are too trendy to be a favorite for years to come. That’s where Cole Haan’s Lux Pinch Penny Loafers ($158) come in. These…
Bloomberg: Q&A with Hasbro CEO Chris Cocks on the toymaker’s gaming push, licensing deals, and more; Monopoly GO! has earned $3B+ in revenue since its April 2023 launch — Monopoly GO! — has become one of the top mobile games of all time and grossed billions in revenue since it launched last year. View Original Source Here
08 Aug 2024 6 New Fantasy Novels for Fans of The Wheel of Time If The Wheel of Time has enchanted you with its epic world-building and rich storytelling, you’re in for a treat! We’ve gathered six new fantasy novels that capture the same sense of wonder and adventure. Dive into these immersive worlds, where epic quests, intricate magic systems, and unforgettable characters await. Get ready to embark on your next grand journey! Finding (The Goddess of Destruction Book 1) by Veronica Ford Release Date: July 31 2021 Sachi has given up hope and hardened her heart. Addon wants only…
Parasites take an enormous toll on human and veterinary health. But researchers may have found a way for patients with brain disorders and a common brain parasite to become frenemies. A new study published in Nature Microbiology has pioneered the use of a single-celled parasite, Toxoplasma gondii, to inject therapeutic proteins into brain cells. The brain is very picky about what it lets in, including many drugs, which limits treatment options for neurological conditions. As a professor of microbiology, I’ve dedicated my career to finding ways to kill dangerous parasites such as Toxoplasma. I’m fascinated by the prospect that we…
If it’s not on Netflix, or Hulu, or Max, how does anyone watch it? Just last month, Netflix announced they would be removing over 20 movies from its streaming catalog. Blockbusters like Sandra Bullock’s 2009 film The Blind Side and Jim Carrey’s 1997 comedy Liar Liar are just two of the many that are about to vanish from the streaming world. And since they are not holding a spot on any other platforms, the only chance for someone to see it is if they rent it. (It currently costs $4.29 to rent Liar Liar on Prime Video, by the way.)…
Katherine Heigl‘s net worth in 2024 has captured the attention of fans and financial observers eager to understand how the Hollywood star has accumulated her wealth. With a career spanning television, film, and production, Heigl has successfully made her mark in the entertainment industry and built a substantial financial portfolio. Let’s explore Katherine Heigl’s income sources and see how she has solidified her financial status in Hollywood. What is Katherine Heigl’s net worth in 2024? Katherine Heigl has an estimated net worth of $30 million in 2024. Katherine Heigl’s 2024 net worth stems from her TV and film career, including…
During a presentation yesterday at a D23 fan event in Anaheim, California, Disney announced that Trent Reznor’s groundbreaking group, Nine Inch Nails, will handle the score for Tron: Ares, the third installment of the cyber-futuristic science fiction film series, set for release in October 2025.The core members of the band, Reznor and Atticus Ross, have scored more than a dozen films, from 2010’s The Social Network to this year’s Challengers, but the new Tron movie will be the first score attributed to Nine Inch Nails. It will also feature new original songs from the band, its first since the fifth…
Whilst I started my career in fashion, I have shimmied between here and the world of interiors. I adore both and have found that your tastes in fashion often inform your design decisions—or at the very least, they reflect one another in some capacity. Like the clothes you wear, the atmosphere of your home deeply impacts your mood and day-to-day life. The sense of calm, energy or creativity your space evokes can do so much for you, therefore, it’s worth prioritising your decor and furniture as highly as your wardrobe.In noticing this cool conversation between clothes and well, clothes for…
Ola Electric Mobility’s shares surged 20% on their trading debut in Mumbai on Friday, valuing the company at $4.8 billion, as investors bet on increasing adoption of electric vehicles in the world’s largest market for two-wheelers.The stock had listed flat to its initial public offering (IPO) price of 76 rupees before rising to 91.20 rupees in a broader market that was up 1%.Ola Electric’s $734 million IPO is India’s biggest so far in 2024. The company is the leading player in a country where adoption of EVs is still low, but rising, as Prime Minister Narendra Modi’s government promotes clean…
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Sepsis occurs when one’s immune system has an extreme response to an infection. It’s a life-threatening condition: globally, it accounts for about 11 million deaths — 20% of all deaths per year.And it doesn’t just affect adults. In 2020, 2.4 million newborn babies died of sepsis in the first month of their lives. Most of these deaths happened in sub-Saharan Africa.The main treatment for sepsis is antibiotics. However, the overuse and misuse of antibiotics in human medicine and agriculture has led to antimicrobial resistance — a process in which bacteria, fungi and parasites have developed the ability to resist the…
Critic’s Rating: 4.4 / 5.04.4You shouldn’t mess with fate. We’ve all heard that. Oh, but it’s so tempting when a handsome stranger appears in your dreams, and he’s more alluring than any man in real life. My Dreams of You explores that dilemma when Grace (Skyler Samuel) dreams of a handsome stranger, only to learn that her dream weaver made an error and that they weren’t supposed to meet in dreamland. (Courtesy of Hallmark Media) Dreams are often our intimate desires or fantasies, which explains why Grace (Skyler Samuels) dreamed of Michael (Kapil Talwalkar). He was hot and attentive to…