Model of EV-mediated V30M-TTR cell deposition in ATTRv amyloidosis patients, compared to processes in healthy controls. Credit: Kanazawa University Amyloidosis is the collective name for a group of diseases characterized by the deposition of amyloids—insoluble proteins that form due to the misfolding and aggregation of soluble proteins—outside of cells. Such depositions lead to cellular dysfunctions, and take place in patients with Alzheimer’s disease, Parkinson’s disease and dementia. In the disease called hereditary (variant) transthyretin amyloidosis (abbreviated ATTRv amyloidosis), variants of the transthyretin (TTR) gene lead to TTR amyloid deposits in several organs, with symptoms including muscle weakness and cardiac failure.…
Author: Admin
Arcade Fire brought the confetti for their celebratory performance of “Unconditional I (Lookout Kid)” at the 2022 Juno Awards on Sunday. Watch the performance below. The Canadian collective played the latest single from their sixth album WE sans the swaying, inflatable dancers that debuted at Arcade Fire’s surprise Coachella set and were later showcased in the song’s music video. But their ebullient and unpredictable energy remained as the band charged through a spirited rendition. Instead, the group was joined by a percussion section of precocious youngsters who not only brightened the stage with beaming smiles but also drove home the…
From a thorn in Chief Brody’s side to a real life Chief Brody.The immortal classic Jaws was set on the fictional New England island of Amity, but the movie was mostly filmed on the real New England island of Martha’s Vineyard. And this week, the real Martha’s Vineyard, selected a new chief of police: Jonathan Searle. And in a twist of fate so beautiful it feels like something out of a movie, Jonathan Searle appeared in Steven Spielberg’s Jaws as one of the kids making life miserable for Chief Brody, when they disguise themselves as a shark and cause havoc on the beaches of…
Read The Full Article Here
[Warning: The below contains MAJOR spoilers for the A Million Little Things Season 4 finale “Just in Case.”] A Million Little Things pulled the rug out from under us, with one reveal we’d expected and another that changed everything we thought about recent episodes. First of all, Anna (Erin Karpluk) did kill her ex-husband, Peter (Andrew Leeds) — the teacher who’s assaulted Sophie (Lizzy Greene) — albeit accidentally and was arrested after confessing. Meanwhile, Gary (James Roday Rodriguez) and Maggie (Allison Miller) found out they’re having a baby, but then Rome (Romany Malco) and Regina (Christina Moses) watched one of…
Sophie Turner embraced the spring heat, stepping out in just an oversized blue button-down and no pants while out with her husband Joe Jonas at the Beverly Hills Hotel yesterday. The two took a limo to grab lunch on Sunset Boulevard. Turner and Jonas are based in Miami now. The couple is expecting their second child later this year. PETEBACKGRID Turner spoke about their choice to move to Florida in her ELLE UK interview, and how they feel about expanding their family. They welcomed their first child, a daughter named Willa, in July 2020.On having a second child, Turner told…
Goodbye iPod, hello Eyes Pod. According to a report by Bloomberg’s Mark Gurman, Apple has demonstrated a new Apple-made VR headset to its board. Such a product has been rumored for a while and has reportedly been in development at Apple since 2015. We don’t yet know what it looks like or much about its features. It could be weeks, months, or even a couple years before an Apple headset surfaces, but the takeaway is that the device does indeed seem to exist.The dip into virtual-reality hardware has been controversial within the company, with pushback and disagreements between Apple brass,…
Even half a century after a drug comes on the market, scientists can still learn new things about how it works. New research from University of Pittsburgh neuroscientists provides a rare look at how Ritalin affects activity in the brains of animals, providing a deeper understanding of how groups of brain cells govern attention and pointing to new possible uses for the stimulant. Around one in 11 children in the U.S. are prescribed stimulants like methylphenidate (also known by its brand name Ritalin) to improve attention and focus in people with attention-deficit/hyperactivity disorder, or ADHD. Many more adults, an estimated…
Morgan Wallen scored his fourth No. 1 debut, and his fifth leader overall, on Billboard‘s airplay-, streaming- and sales-based Hot Country Songs chart as “Thought You Should Know” blasted to the top of the May 21-dated list. Wallen co-wrote the song with Nicolle Galyon and Miranda Lambert, and Joey Moi produced it. The emotionally charged ballad is dedicated to Wallen’s mother, Lesli. Explore Explore See latest videos, charts and news See latest videos, charts and news If you need a guide to follow along with the country singer’s “Thought You Should Know,” find the lyrics below: What’s goin’ on, mama?Something just…
We come to it, at last, the grand finale of Marvel’s best TV show to date. Does Moon Knight go out with a bang? Does it succinctly tie up all of its loose ends? Does anything happen to Ethan Hawke’s hair? Were any of my predictions correct? Read on to find out.I haven’t been shy about my admiration for Moon Knight. There’s a lot of love about this show from the characters to the Egyptian mythology to the examination of Dissociative Identity Disorder. The pair of episodes leading up to the final act put superheroic action on the back burner…
What’s the story behind the story? What inspired you to write And So We Dream? I think I wanted to capture the way life was when I was growing up – or, rather, to create an idealized version of it. And I’ve always believed in the power of dreams, of shaping your life the way you want it to be. What’s your favorite genre to read? Is it the same as your favorite genre to write? Very broadly speaking, Women’s Fiction, the same genre I write in. What books are on your TBR pile right now? Amor Towles’ Rules of…
[WARNING: The following contains MAJOR spoilers for The Kardashians Season 1, Episode 6, “This is a Life or Death Situation.”] The most surprising thing The Kardashians Season 1 has revealed is that Kendall Jenner doesn’t know how to slice cucumbers. And The Kardashians Season 1 Episode 6, “This Is a Life or Death Situation,” seals the long-forming feeling that this show just isn’t necessary. The episode’s title isn’t hyperbolic. Kim Kardashian spends the entire installment working to commute the sentences of two death-row inmates, Brandon Bernard and Julius Jones. Tragically, Bernard was executed on December 10, 2020. And content warning…
From its humble medieval origins as a medicinal agent, vodka has conquered the world. In 2020, the worldwide sales of vodka earned around $45 billion, and U.S. consumers alone guzzled 189.7 million gallons (862.4 million liters) of the potent alcoholic beverage, according to Beverage Dynamics, a national magazine focused on retail alcohol sales. But what is vodka made from?To produce vodka, you must first ferment any foodstuff that contains sugar or starch, then distill the product to increase its alcohol content. (Fermentation means feeding sugar to yeast, so that the yeast can produce alcohol.) Vodka can made from fermented grains such…
Photography by BRYAN WHITELY This is Texture Talk, a column that deep dives into the dynamic world of curly hair, from crowns of curls that are free flowing to strands that are tucked away in a protective style. By Sumiko Wilson Date May 12, 2022 America’s Next Top Model may not have gotten everything right when it comes to what the fashion industry truly entails, but the drama between contestants did have a certain degree of accuracy — at least according to model and reality-television star Brittnee Blair. Her own foray into the fashion world picked up speed when she…
Sources: Broadcom is in ongoing talks to acquire VMware, but a deal is not imminent — Chipmaker Broadcom Inc (AVGO.O) is in talks to acquire cloud service provider VMware Inc (VMW.N), people familiar with the matter told Reuters. — Negotiations between Broadcom and VMware are ongoing and a deal is not imminent, the sources said. Read The Full Article Here
Graphical abstract. Credit: Ecological Indicators (2022). DOI: 10.1016/j.ecolind.2022.108762 Changes in precipitation patterns under global climate change affect plant biodiversity in terrestrial ecosystems, with potentially important implications for ecosystem function and processes. However, knowledge about how altered precipitation affects different aspects (e.g., species, functional, and phylogenetic diversity) of plant community diversity and how these impacts propagate to affect ecosystem multifunctionality is limited. Recently, researchers from the Northwest Institute of Eco-Environment and Resources of the Chinese Academy of Sciences (CAS) found that species diversity plays a more important role in mediating the response of ecosystem multifunctionality to altered precipitation. Related results were…
On May 9, Young Thug was arrested at his Atlanta home after being named in a broad 56-count gang indictment. According to the indictment, the rapper and 27 other people, including Gunna, allegedly conspired to violate the Georgia criminal racketeering law. The government claims that YSL—Young Thug’s rap collective and label also known as Young Stoner Life—is a criminal gang with ties to the national Bloods organization.Specifically, the 28 people named in the indictment are all charged with conspiracy to violate the state’s Racketeer Influenced and Corrupt Organizations Act, or RICO. That’s Georgia’s version of the federal law originally designed…
Holy Spider – first-look review 3 && args[2] === 2 && typeof args[3] === ‘boolean’ ) { gdprApplies = args[3]; if (typeof args[2] === ‘function’) { args[2](‘set’, true); } } } else if (args[0] === ‘ping’) { var retr = { gdprApplies: gdprApplies, cmpLoaded: false, cmpStatus: ‘stub’ }; if (typeof args[2] === ‘function’) { args[2](retr); } } else { queue.push(args); } } function postMessageEventHandler(event) { var msgIsString = typeof event.data === ‘string’; var json = {}; try { if (msgIsString) { json = JSON.parse(event.data); } else { json = event.data; } } catch (ignore) {} var payload = json.__tcfapiCall; if…
This content contains affiliate links. When you buy through these links, we may earn an affiliate commission. Bucks County in Pennsylvania has seen an increase in book challenges mostly led by a group called “Woke Pennsylvania”. In response, the school board has drafted a new Library Materials policy, one that specifically prohibits “explicit or implied written descriptions of sexual acts” and “visual depictions of nudity or implied nudity.” This would mean that a book like In the Night Kitchen by Maurice Sendak or puberty books depicting bodies would be banned from elementary libraries. The Bucks County Beacon ran this policy…
Why is the world filled with so much hatred and evil? There should be no place for it, but sadly, it’s just all around. They touched on that during Grey’s Anatomy Season 18 Episode 18, which was timely, particularly in covering a heinous, bigoted attack against a patient during AAPI Heritage Month. And with a gold star class of successful Asian-American medical professionals, we both celebrated their achievements while also recognizing their reality as minorities in a country that treats them as “others” and brutally attacks sweet, older ladies for simply existing. For a penultimate finale installment, the hour was…
For movie premieres, fundraisers, and the Met Gala, Blake Lively has worked closely with designers to create statement-making looks. What is equally impressive is that the actor comes up with her own ensembles, without the help of a stylist — having famously forgone a stylist for the entirety of her career. She shared some insights into her style both on and off screen in the latest installment of the Vogue Life in Looks series. The 34-year-old star spoke about the influence of New York City on her style, as the backdrop of her breakout show, “Gossip Girl,” and the place…
Sources: Broadcom is in ongoing talks to acquire VMware, but a deal is not imminent — Chipmaker Broadcom Inc (AVGO.O) is in talks to acquire cloud service provider VMware Inc (VMW.N), people familiar with the matter told Reuters. — Negotiations between Broadcom and VMware are ongoing and a deal is not imminent, the sources said. Read The Full Article Here
In All About History issue 117, on sale now, you can uncover the origins of the Olympian gods and learn how the myths the Ancient Greeks built around their deities helped to inform their civilization. Breaking down the stories of Zeus, Athena, Hades, Poseidon and more, All About History connects the dots between Greece and its neighboring cultures. You can also find out why these gods were so important to regional identity, such the important connection between Athena and her namesake city of Athens.Annette Giesecke is your guide through the twisted tales of Greek mythology, giving you a crash course in the…
Primus had a couple of potentially intimidating fans on Friday (May 14th) at Toronto’s Massey Hall, where Rush members Geddy Lee and Alex Lifeson were in attendance. After all, Primus are paying tribute to Rush during this tour, but it appears they didn’t disappoint the prog-rock legends. Primus have been playing Rush’s A Farewell to Kings in its entirety, along with select Primus cuts, on the ongoing tribute run. When the route passed through Rush’s native Canada, it only made sense for Lee and Lifeson to drop by and check it out (Lee had previously given Primus’ Les Claypool some…
Vortex review – Equal parts absorbing and agonising 3 && args[2] === 2 && typeof args[3] === ‘boolean’ ) { gdprApplies = args[3]; if (typeof args[2] === ‘function’) { args[2](‘set’, true); } } } else if (args[0] === ‘ping’) { var retr = { gdprApplies: gdprApplies, cmpLoaded: false, cmpStatus: ‘stub’ }; if (typeof args[2] === ‘function’) { args[2](retr); } } else { queue.push(args); } } function postMessageEventHandler(event) { var msgIsString = typeof event.data === ‘string’; var json = {}; try { if (msgIsString) { json = JSON.parse(event.data); } else { json = event.data; } } catch (ignore) {} var payload…
Read The Full Article Here
The season is over for NBC’s Law & Order lineup, ABC’s Station 19 and Big Sky, FX’s Atlanta and Halo on Paramount+ in a flurry of season finales, while canceled CBS comedies The United States of Al and How We Roll take their final bow. AMC+ presents a stylized series version of the 1960s-era spy caper The Ipcress File. Emmy Rossum stars in and produces Angelyne, a limited series about a woman who sought fame by putting her image on L.A. billboards. In the tradition of the Manning brothers during Monday Night Football, Joe Buck and golf analyst Michael Collins…
Credit: CC0 Public Domain A team from the Tulane University School of Science and Engineering has developed a new family of two-dimensional materials that researchers say has promising applications, including in advanced electronics and high-capacity batteries. Led by Michael Naguib, an assistant professor in the Department of Physics and Engineering Physics, the study has been published in the journal Advanced Materials. “Two-dimensional materials are nanomaterials with thickness in the nanometer size (nanometer is one millionth of a millimeter) and lateral dimensions thousands of times the thickness,” Naguib said. “Their flatness offers unique set of properties compared to bulk materials.” The…
Try as we may, right now, all we can seem to think about is 2022 and the new trends that come with it. If you’re a loyal Who What Wear reader, as I suspect you might be, you’ll have already devoured our spring/summer 2022 trend report, outlining every notable look, garment, and accessory we saw during September’s Fashion Month showcase. If this, however, is not the case, I suggest you take a look at it and meet me back here once you’re up to speed.Okay, now that you know precisely what the new collections look like, let’s talk about how to…
Blockchain analysis platform Chainalysis has been roped in as a partner by Bank of New York Mellon (BNY Mellon) to facilitate the tracking of user transactions. Chainalysis, which provides services to traditional financial institutions, also provides crypto compliance tools which is what BNY Mellon is interested in as part of the bank’s risk management programme. BNY Mellon is the largest holder of securities, commodities, and cash in the world, managing around $46.7 trillion (roughly Rs. 35,31,64,080 crore) worth of assets across 35 countries.Through this partnership, BNY Mellon will use the software provided by Chainalysis to track, record, and utilise data…