Close Menu
    Facebook X (Twitter) Instagram Pinterest YouTube LinkedIn TikTok
    TopBuzzMagazine.com
    Facebook X (Twitter) Instagram Pinterest YouTube LinkedIn TikTok
    • Home
    • Movies
    • Television
    • Music
    • Fashion
    • Books
    • Science
    • Technology
    • Cover Story
    • Contact
      • About
      • Amazon Disclaimer
      • Terms and Conditions
      • Privacy Policy
      • DMCA / Copyrights Disclaimer
    TopBuzzMagazine.com
    Home»Science»New study confirms bioengineered RSV protein vaccine evokes protective immune
    Science

    New study confirms bioengineered RSV protein vaccine evokes protective immune

    By AdminApril 12, 2022
    Facebook Twitter Pinterest LinkedIn Tumblr Email

    Close interactions with infectious disease set both University of California, Santa Cruz graduate student Ana Nuñez Castrejon and Associate Professor of Biomolecular Engineering Rebecca DuBois on the path of studying Respiratory syncytial virus (RSV), a common and sometimes dangerous respiratory disease for which there is not currently a vaccine. The two researchers recently marked a major milestone in their effort to create an effective vaccine for the virus with the publishing of their paper “Structure-based design and antigenic validation of respiratory syncytial virus G immunogens” in the Journal of Virology.

    For fifth-year Baskin Engineering student and the paper’s lead author Nuñez Castrejon, a bout of pneumonia that lingered for months when she was an undergraduate student sparked her interest in studying respiratory illnesses. For DuBois, watching her child go through a serious infection of RSV, which can cause severe respiratory infections in infants/children and the elderly, led her to study the disease.

    “We have all of these wonderful childhood vaccines that have eliminated so much childhood disease, but there are still a lot of infectious diseases that are really tough on children, and RSV is one of those that causes hospitalizations in children,” DuBois said.

    Now, the team focuses on bioengineering the structure of RSV’s G protein, which attaches the virus to host cells. The researchers altered the structure of the protein to eliminate its negative effects and while still eliciting a protective response from the immune system in the form of antibodies that bind to the G protein.

    The researcher’s 2021 paper showed that their engineered G protein was able to stimulate a stronger antibody response than the native G protein. However, it was unclear if the engineered G protein still “looked like” the native protein does on the surface of the virus. The newest study confirms that this engineered G protein looks the same and is recognized by human RSV-fighting antibodies.

    “My paper shows that the engineered mutation in the protein doesn’t disrupt the ability of antibodies to bind it, so when it is used as a vaccine antigen it is possible to elicit these protective antibodies in animal models, and hopefully in the future people will be protected from the disease,” Nuñez Castrejon said.

    This paper is similar to a 2017 publication crucial in the creation of the COVID-19 vaccine which described how to bioengineer the coronavirus’s Spike antigen to induce more and better antibodies, a strategy that was used to create to design the Moderna, Pfizer, J&J, and Novavax vaccine Spike antigens. Both papers use structural biology to ensure that an engineered version of a virus can be recognized by the immune system to fight the actual virus.

    “This is the same kind of foundational work that allowed scientists to design the coronavirus vaccine so quickly and enable it to look exactly like it does on the surface of the virus, and even better,” DuBois said. “I think what people are coming to realize is that we can make vaccines that stimulate immune responses that are better than you get from infection, if we can engineer the antigens in a way that really exposes the weaknesses of the virus.”

    Research in DuBois’s lab differs from other efforts to develop a RSV vaccine in their approach to studying the virus’s proteins. Many researchers are focused on altering the structure of the RSV F protein, which fuses the virus and host cell membranes together to get the virus’s genetic information into cells.

    But late-stage clinical trials of vaccines using this approach show only a 60 to 70 percent protection against infection, which is promising but lower than what would be hoped for for an important pathogen like RSV.

    In the short term, the researchers are looking to further analyze results from collaborators at the University of Georgia as to how their engineered protein affected disease symptoms in mice, and will continue to engineer the RSV G protein to produce stronger immune responses. In the next five years, they hope to develop an RSV vaccine using their engineered protein that is ready for clinical trials.

    DuBois and Castrejon Nuñez are also collaborating with the biotechnology company Trellis Bioscience, which is investigating the use of monoclonal antibodies to treat infants with RSV infection and severe lung congestion.

    Story Source:

    Materials provided by University of California – Santa Cruz. Original written by Emily Cerf. Note: Content may be edited for style and length.

    Read The Full Article Here

    Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

    Related Posts

    Science history: Invention of the transistor ushers in the computing era — Oct. 3, 1950

    October 3, 2025

    Antarctica may have crossed a tipping point that leads to rising seas

    October 2, 2025

    Viewing teens more positively may help their school performance and strengthen family bonds

    October 2, 2025

    Bering Land Bridge emerged much later than we thought it did, new study finds

    October 1, 2025

    We finally know why a belly button becomes an ‘innie’

    October 1, 2025

    Plant receptors for nitrogen-fixing bacteria evolved independently at least three times, study reveals

    September 30, 2025
    popular posts

    Kate Moss, Gigi Hadid and Rosie HW all Wore Cropped Jackets in Paris This Week

    Why The Batman should win the Oscar for Best Cinematogaphy

    The Rookie Season 5 Episode 15 Review: The Con

    Britney Spears’ Memoir Release Date and Cover Reveal

    Discover a classic, booze-fuelled sequence of female self discovery

    The Ugly Lessons of Silicon Valley Bank’s Collapse

    Could AI play a role in locating damage to the

    Categories
    • Books (3,447)
    • Cover Story (8)
    • Events (19)
    • Fashion (2,547)
    • Interviews (45)
    • Movies (2,747)
    • Music (3,031)
    • News (161)
    • Politics (6)
    • Science (4,597)
    • Technology (2,742)
    • Television (3,472)
    • Uncategorized (932)
    Archives
    Facebook X (Twitter) Instagram Pinterest YouTube Reddit TikTok
    © 2025 Top Buzz Magazine. All rights reserved. All articles, images, product names, logos, and brands are property of their respective owners. All company, product and service names used in this website are for identification purposes only. Use of these names, logos, and brands does not imply endorsement unless specified. By using this site, you agree to the Terms of Use and Privacy Policy.

    Type above and press Enter to search. Press Esc to cancel.

    We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of ALL the cookies.
    Do not sell my personal information.
    Cookie SettingsAccept
    Manage consent

    Privacy Overview

    This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
    Necessary
    Always Enabled
    Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
    CookieDurationDescription
    cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
    cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
    cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
    cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
    cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
    viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
    Functional
    Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
    Performance
    Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
    Analytics
    Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
    Advertisement
    Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
    Others
    Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
    SAVE & ACCEPT