HomeScienceBlood clotting research holds hope for sepsis

Blood clotting research holds hope for sepsis

master mentalism tricks

Researchers from the University of Birmingham, UK, who identified a novel mechanism for platelet activation in pathogenic blood clotting (thrombosis) are now turning their attention to sepsis.

Identified by Associate Professor Julie Rayes and Dr Martina Colicchia from the Birmingham Platelet Group, and described in a recent paper in Blood, this previously unknown axis comprises platelet receptor glycoprotein I alpha (GPIb?), and an anti-microbial protein S100A8/A9, which is released from activated immune cells.

The mechanism is not blocked by classical anti-platelet drugs currently used to treat arterial thrombosis, and is distinct from the well-described ‘clotting cascade’ that limits blood loss following injury.

Dr Rayes explains: “When clots are formed at the site of a vascular injury, two main populations of platelet are seen. Highly activated and aggregated platelets are located at the core of the clot, while procoagulant platelets are present at the shell around the core and support the generation of fibrin which stabilizes the clot.

“The S100A8/A9-GPIb? axis does not induce platelet aggregation but it does induce the formation of procoagulant platelets and accelerates fibrin activation and thrombosis. This axis might be more relevant in disease states where the activation of innate immune cells and platelets play a pivotal role in clotting.”

High levels of S100A8/A9 are seen in the blood in thrombo-inflammatory diseases including myocardial infarction (MI), deep vein thrombosis (DVT) and infections such as COVID-19 and sepsis, and their presence correlates with thrombotic complications, and worse outcomes for patients.

The researchers believe this novel mechanism may be relevant in thrombosis observed under chronic inflammatory conditions and acute infections and believe that the interaction of S100A8/A9 with multiple receptors* makes it an interesting target to limit both clotting and inflammation during sepsis.

Dr Rayes said: “Thrombosis is a major complication during infection, so drugs are needed that target pathogenic clotting while maintaining vascular integrity and normal clotting process (haemostasis). By selectively targeting S100A8/A9, we aim to target a key pathogenic inflammatory and thrombotic molecule to limit both inflammation and thrombosis during infection.”

Associate Professor Rayes presented at the 63rd American Society of Hematology (ASH) Annual Meeting on Monday December 12, 2022 (16.30-18.05 CST). She expects to publish the results of the sepsis study in 2023.

University of Birmingham Enterprise has filed a patent application covering the targeting of the S100A8/A9-GPIb? axis in the treatment and prevention of thrombosis in chronic inflammatory and thrombotic diseases and is now seeking partners for commercial development or licensing.

Read The Full Article Here

trick photography

Popular posts

Netflix Reveals First Look at Live-Action ‘One Piece’ Series
Rami Malek to Lead Buster Keaton Miniseries From Matt Reeves
Despite Cobra Kai Ending, EPs Tease ‘More Karate Kid Stories’
Captain America: New World Order Adds Xosha Roquemore
Major League Wrestling Finds a New Home on Reelz
The Ark’s Cast and Crew Gave Us the Exclusive Scoop
10 Best Episodes of ‘Dawsons Creek,’ Now 25 Years Old
Fantasy Island Exclusive Sneak Peek: Roarke Welcomes Her Very First
Exclusive Interview with RichGA
Noah Assad On Working With Bad Bunny From The Beginning,
Frank Ocean Restocks Blonde Vinyl for the First Time in
Cordae & Anderson .Paak Hit the Club, Ponder Relationships in
So Long, High Heels—These Are the Party Shoes Every Fashion
6 Best Freckle Pens for a Natural, Sun-Kissed Look
30 ASOS Dresses That You’ll Love and Wear Year-Round
Mikayla Nogueira Mascara Scandal: Should We Ever Trust Influencers?
Interview with Measha Stone, Author of Ravaged Innocence
CATHERINE, CALLED BIRDY, Sexism, Ableism, and Me: What I Learned
Your Guide to This Year’s ALA Youth Media Awards
Interview with John Etterlee, Author of Blood Red
BBC documentary used face-swapping AI to hide protesters’ identities
Joint effort discloses deep divergence of a mysterious porpoise
How to watch the rare green comet whiz past Earth
Double Disaster: Wildfires Followed by Extreme Rainfall Are More Likely
Meta Slams Apple, Says Ad Policy ‘Undercutting Others’ in Digital
Snap Founder Slams the Metaverse, Says People Prefer Augmented Reality
Lina Khan’s Plan to Liberate US Workers
Crypto a Viable Retirement Plan for Most Millennials, Gen Zs