Family legacy has long captivated our imagination, whether in the form of domestic thrillers like The Family Upstairs by Lisa Jewell; classic stage plays like Shakespeare’s Hamlet; sweeping historical epics like Jeffrey Eugenides’s Middlesex; or intimate personal narratives like Louisa May Alcott’s Little Women. From hidden betrayals to whispered curses, the deeper one delves into a family’s history, the more evident it becomes that the past can cast a long, haunting shadow over the present.

Recent discoveries in psychology and genetics have reinforced this theme, suggesting that our ancestors’ experiences may shape not only our mental outlook but also our biological predispositions.
This interplay between science and storytelling offers a compelling lens through which to explore the enduring influence of bloodlines — a theme vividly brought to life in The Medici Curse, a Gothic thriller that intertwines family secrets, psychological turmoil, and the weight of inherited trauma.
The Psychological Legacy: Unspoken Traumas and Resilience
Modern psychology provides some of the clearest insights into how a family’s history influences its descendants. Building on the pioneering work of psychiatrist Murray Bowen, contemporary researchers have used longitudinal studies to explore how unspoken traumas or unresolved conflicts reverberate through generations. Research reveals an intriguing truth: individuals often exhibit heightened stress or anxiety that correlates with an often-unknown originating event in the family line.
This phenomenon, known as intergenerational trauma, underscores the profound impact of familial narratives on mental health. Survivors of war, like Japanese internment camp prisoners or Holocaust survivors, can pass down heightened stress responses via epigenetic changes — chemical tags that alter gene expression. Recognition is the key to breaking the cycle and developing healthy relationships.
In The Medici Curse, protagonist Anna de’ Medici Rossi grapples with this very concept. Anna is haunted by fragmented memories of her mother’s tragic death and the whispered accusations that she was responsible. Not just that, but also the manner in which all the Medici women in her family line have died. When she returns to her family’s opulent Tuscan villa after sixteen years, the night terrors that plagued her childhood resurface. Those terrors mirror the psychological burden of unresolved family trauma. As Anna discovers hidden rooms and uncovers long-buried secrets, she confronts the possibility that her family’s troubled legacy has shaped her in ways she cannot fully comprehend.
Meanwhile, psychologists have shed light on the power of developing a coherent narrative around one’s ancestral past. Understanding the stories of our forebears — be they tales of courage, scandal, or survival — can foster personal resilience and psychological growth.
By reframing inherited narratives, individuals can transform personal burdens into sources of strength. Anna’s journey to unravel the truth about her mother’s death and the missing heirloom necklace becomes a quest not only for answers but also for self-understanding and redemption.
The Biological Dimension: Epigenetics and Inherited Stress
Beyond psychology, the emerging field of epigenetics has revolutionized our understanding of inherited traits and behaviors. While traditional genetics focused on physical traits or susceptibility to illness, scientists like Michael J. Meaney and Moshe Szyf have shown that environmental stressors — such as famine, war, or emotional upheaval — can leave “marks” on genes. The marks can influence genetic expression in future generations. Studies demonstrated that severe maternal stress in rodents can produce epigenetic changes observable in subsequent generations. In humans, this interplay between genes and environment is more complex, but the takeaway is compelling: the circumstances our ancestors faced may subtly shape our biology, lending scientific credence to the idea of inherited family burdens.
This research provides real-world plausibility to plotlines once relegated to the realm of superstition. While older stories might have invoked literal family curses, contemporary authors can — knowingly or not — draw on epigenetic undercurrents when depicting generations of misfortune or recurring psychological struggles. In The Medici Curse, the legend of a family curse tied to a missing heirloom necklace resonates with the real-world notion of “inherited stress markers.” Anna’s suspicion that something deeper than chance is at work mirrors the scientific understanding that the traumas of our ancestors can leave an indelible mark on our lives.
Literary Echoes: Family Sagas and Collective Memory
Other novelists have explored family sagas with an emphasis on resilience and the enduring power of collective memory. Kristin Hannah, for instance, often depicts how decisions made decades earlier continue to ripple through subsequent generations. In The Nightingale and The Four Winds, Hannah’s characters grapple with the weight of inherited struggles, whether arising from the scars of war or the hardships of the Great Depression. These narratives highlight how the past shapes the present, even when the connections are not immediately visible.
Isabel Allende’s The House of the Spirits layers its ghosts and hidden scandals across several lifespans, exploring how a single act of betrayal can alter a family’s trajectory. Similarly, Ann Patchett’s The Dutch House places siblings at the mercy of a grand estate bound up in the secrets of their mother’s departure, in this way mirroring Anna’s quest in The Medici Curse to uncover the truth behind her mother’s death. These stories remind us that family secrets, no matter how deeply buried, have a way of resurfacing, often with profound consequences.
Gothic fiction, in particular, has long been a vehicle for exploring family legacy. Daphne du Maurier’s Rebecca delves into the psychological grip of a deceased wife on a family, while Shirley Jackson’s We Have Always Lived in the Castle examines the isolation and paranoia that can arise from unresolved family trauma. More recently, Silvia Moreno-Garcia’s Mexican Gothic and Isabel Cañas’s The Hacienda have reimagined the genre, blending family secrets with supernatural elements to explore the enduring power of the past.
Rewriting Inherited Stories: Hope and Transformation
Yet, for all the cautionary tales, there remains hope in the idea of rewriting inherited narratives. If we accept that an epigenetic or psychological “script” can be passed down from generation to generation, we also acknowledge that new experiences, revelations, and choices might help us transcend the fates we once believed were sealed. Anna’s fierce drive to uncover the truth of her mother’s demise in The Medici Curse exemplifies this potential for reinvention. Recognizing the ways family legends shape us opens the door to using that same awareness as a tool for forging a more authentic and self-directed future.
In the end, whether these legacies are cloaked in superstition or grounded in science, our fascination with them runs deep because they speak to something fundamental: our desire to understand ourselves in the context of those who came before us. This tension between destiny and autonomy — highlighted by novelists and bolstered by emerging research — reminds us that we inhabit an intricate web of genetic, emotional, and narrative strands. The Medici Curse, with its Renaissance grandeur and modern-day dilemmas, ties the old world to the new, proving that family secrets, no matter how ancient, still have the power to change one’s path.