Scientists at Scripps Research have invented a way to image, across different tissues and with higher precision than ever before, where drugs bind to their targets in the body. The new method could become a routine tool in drug development. Described in a paper in Cell on April 27, 2022, the new method, called CATCH, attaches fluorescent tags to drug molecules and uses chemical techniques to improve the fluorescent signal. The researchers demonstrated the method with several different experimental drugs, revealing where — even within individual cells — the drug molecules hit their targets. “This method ultimately should allow us,…
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“Curling eyelashes is a non-negotiable step for me—it’s an intricate part of my routine when I’m working on clients,” says makeup artist Patrick Ta, a favorite of Gigi Hadid and Adriana Lima He loves this Kevyn Aucoin classic “because it has the perfect curve even on the roundest of eyes.”Kevyn Aucoin’s curler is also the number one pick for Rommy Najor, who works with Martha Hunt and Doutzen Kroes. “It’s slightly wider than the [cult-favorite] Shu curler, which catches more lashes on the ends,” she says. “Also, it doesn’t require a strong pinch to the lash in order to curl…
The other thing the Evo Lite+ offers is better low-light performance. The Air 2S has a maximum ISO of 6,400 in manual video capture, or 1,600 if you’re shooting D-log. The Evo Lite+ can shoot ISO 48,000, thanks to a dedicated Night Mode. Now, that number might sound like a recipe for noisy, mostly useless video, but surprisingly, it’s not. Autel’s Dark Mode algorithm manages relatively crisp video without scene-ruining levels of noise, even in moonlight. That said, I have never actually flown a drone at night (other than to test this feature), so how useful this is will depend…
In 2021 Republican legislatures in 19 states passed 34 laws that restricted access to voting in more than a dozen different ways. And those are just the bills that succeeded; hundreds of other provisions, some still under consideration, were introduced nationwide. “The momentum around this legislation continues,” the Brennan Center for Justice, which tracks these efforts, wrote on its Web site. At least 165 restrictive voting bills were already on the docket for this year by mid-January. “These early indicators—coupled with the ongoing mobilization around the Big Lie (the same false rhetoric about voter fraud that drove [last] year’s unprecedented…
Gabriel “Tokkie” du Preez, the adopted son of Die Antwoord’s Yolandi Visser (aka Anri du Toit) and Ninja (aka Watkin Jones), has accused the couple of physical and sexual abuse and exploitation. The allegations surfaced through a 44-minute interview with the South African group’s former filmmaker Ben Jay Crossman and a subsequent sitdown with News24. du Preez and his younger sister were adopted by Die Antwoord in 2010 — when he was just nine years old — under foster parenting agreements with their biological mother. They would go on to appear in music videos like “I Fink U Freeky” and…
Netflix’s Metal Lords is now streaming. The coming-of-age film stars Jaeden Martell, Isis Hainsworth, and Adrian Greensmith with Brett Gelman and Joe Manganiello. Rage Against the Machine’s Tom Morello also serves as the executive music producer for the movie.RELATED: Metal Lords Interview: Game of Thrones Co-Creator D. B. Weiss Discusses Netflix Film“Two kids want to start a heavy metal band in a high school where exactly two kids care about heavy metal. Hunter (Adrian Greensmith) is a diehard metal fan —is there any other kind?— who knows his history and can shred,” says the official synopsis. “His dream in life is to win at the…
This week, NPR and several other major media outlets ran a story about how one Florida man chose to respond to book bans throughout his state. Chaz Stevens is a middle age white activist, known for doing some tongue-in-cheek protests. His latest involves petitioning Florida schools to remove the Bible from libraries because of its inappropriate content for minors. In addition to banning the Bible, his letter to school superintendents across the state asked for any books referencing the Bible to also be pulled. The intention behind this set of book challenges — humorous or not — garnered a lot…
Netflix co-CEO Reed Hastings has revealed that the streamer is open to the possibility of lower-cost, ad-supported subscriptions to help boost the company’s growth. The news came during Netflix’s Q1 earnings interview, where Hastings revealed that the company is hoping to nail down its strategy for ad-supported streaming over the next year or two. “But think of us as quite open to us offering even lower prices with advertising as a consumer choice,” he said. For years, Netflix has been adamant about sticking to subscription-only plans; however, subscriptions have begun to slow in recent times. In fact, according to Variety,…
The recent case of a driverless car that tried to escape its handlers might make us laugh, but it also warns us about what could happen when AI is given a “body”, writes Annalee Newitz Technology | Columnist 2 February 2022 By Annalee Newitz MicroOne/Shutterstock DRIVING in San Francisco is like watching a robot uprising in the making. Last week, I was crossing an intersection, turning from one major downtown thoroughfare onto another, and realised that my vehicle was surrounded by four experimental self-driving cars. They weren’t exactly difficult to spot, their bumpers encrusted with radar and other sensors, their…
After performing at the Grammys in a trench coat and scoring her first Oscar with her brother, Finneas, Billie Eilish is ready to treat her fans to something special at Coachella. Teaming up with Conan Gray, Eilish is launching a pop-up shop that will feature exclusive merchandise for Coachella attendees. The music festival will host an on-site American Express lounge where fans can shop Billie’s sustainable Black Zip-Up Hoodie ($100), which has been reclaimed and made from upcycled deadstock, shelf pulls, retail returns, and gently used apparel. The front of the hoodie will feature black and white silhouettes of Eilish…
The Supreme Court on Friday asked central government whether Bitcoin is illegal in the country or not while hearing a matter relating to the GainBitcoin scam. The court orally enquired central government whether Bitcoins are illegal or not.The court enquiry came while hearing the petition seeking cancellation of bail against Ajay Bhardwaj, one of the co-accused among others in this case. Responding to the court’s question, Additional Solicitor General Aishwarya Bhati said that accused Ajay Bhardwaj is allegedly involved in the fraud of Bitcoins.A bench of Justice DY Chandrachud and Justice Surya Kant, meanwhile, directed accused Ajay Bhardwaj to co-operate…
With a hattrick of wins, The Kid Laroi led from start to finish as the APRA Music Awards returned to Melbourne on Tuesday night (May 3). The teenage superstar has rolled in a purple patch the likes of which few artists see. Now based in Los Angeles, the Sydney-raised artist led the singles and albums charts in the U.S. and Australia in 2021, and, along the way, logged a record-setting stay at the summit of the Billboard Hot 100 with “Stay,” his collaboration with Justin Bieber. At the 2022 APRAs, Laroi nabbed the night’s top prize and the final category…
According to Variety, Blue Bayou filmmaker Justin Chon has found his next project with Apple TV+. This comes hot on the heels of the epic global drama Pachinko, which just recently debuted. Chon has officially signed on to helm and executive produce the first two episodes of the upcoming historical drama titled Chief of War, starring Jason Momoa.RELATED: MGM Wins Jason Momoa & Dave Bautista’s Untitled Buddy Cop MovieChief of War will be co-written and executive produced by Momoa and Thomas Pa’a Sibbett, with Doug Jung set as the showrunner. The epic story follows the unification and colonization of Hawaii from an…
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Judge Lola Carmichael’s court will be back in session this summer on OWN. The cabler revealed Monday that All Rise Season 3 — its first season on the network — will touch down Tuesday, June 7, at 8/7c. The series follows the chaotic, hopeful, and sometimes absurd lives of its judges, prosecutors, and public defenders, as they work with bailiffs, clerks, and police to get justice for the people of Los Angeles amidst a flawed legal system. Among them is newly appointed Judge Lola Carmichael (Simone Missick), a highly regarded and impressive former deputy district attorney who doesn’t intend to…
By Clare Wilson GAP Photos/Anna Omiotek-Tott IN MY garden, bulbs such as snowdrops are coming up. Every year, I wonder if spring is arriving earlier due to climate change. One study from 2006 found that many signs of spring, such as plant species unfurling their leaves, had been hastened by 7.5 days across Europe in the previous 30 years (Global Change Biology, doi.org/b7vmgk). And research published this week has found that UK plants are flowering nearly a month earlier than they did before the mid-1980s, probably due to warmer temperatures from January to April. You might think that warmer weather…
Tia Tia. Photography courtesy of Getty Images We bet Brandy is proud. By Natalie Michie Date April 4, 2022 It would seem that celebrities have taken a page out of the ’90s style book as the spiky updo made its triumphant return at the Grammy Awards this past Sunday. A look that can only be described as business in the front and party in the back (move over, mullet!), it involves slicking back one’s strands into a neat bun, with some loose pieces of hair framing the face and the ends left to fan out in spikes. Doja Cat. Photography…
There’s a reason why pizza is the menu choice of picky preschoolers, hungry teenagers, and discerning foodies alike. With enough cheese, tomato sauce, and arugula, homemade pizzas are a complete meal. They’re irresistible, easy to make, and customizable for a wide range of dietary preferences. Until recently, an aspiring pizzaiolo had no choice but to crank up their kitchen oven to the standard 450 degrees. Now, the best portable pizza ovens can heat up as high as 900 degrees—the perfect temperature for making a crisp, Neapolitan-style pizza in minutes. For the past three years, I’ve memorized recipes, perfected my dough-tossing technique,…
Jhayco (formerly known as Jhay Cortez) had a successful evening at the 2022 Latin American Music Awards on Thursday (April 21), where he was an eight-time nominee. The Puerto Rican singer won song of the year and favorite urban song for his Bad Bunny-assisted “Dákiti,” which he also performed on stage, followed by a presentation of his new single “Sensual Bebé.” Explore Explore See latest videos, charts and news See latest videos, charts and news That same night, the artist born Jesús Manuel Nieves Cortez officially announced his artistic name change to Jhayco at the live, televised event. “It’s something…
James Cameron has been talking about making Avatar sequels since before there was an Avatar. A sequel was announced and planned for as early as 2014, and shooting began on what eventually expanded to four sequels in 2017.But in all that time, Avatar 2 never had an official title. Finally, about five years into production and only about eight months until the film finally premieres in theaters, Disney announced the movie’s full title at the CinemaCon convention is Las Vegas. The movie is called… Avatar: The Way of Water. The studio also announced that the much-anticipated first trailer for the film will play in front of Doctor Strange…
As the climate crisis grows, “cli-fi” books are driving action by showing dark, all-too-possible futures, says climate researcher Bill McGuire. Here are some of his favourites Environment 2 February 2022 By Bill Mcguire Cli-fi provides visions of the future that aren’t yet too late to changeJorn Georg Tomter/Getty Images SCIENTIFIC papers, however well-written, rarely carry the emotional weight of a good story. Stories have been the prime means of imparting knowledge and warnings throughout human history. Even in today’s data-rich world, they hold a visceral clout that no amount of graphs, charts or figures can replace. As a volcanology and climate…
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The HBO sports drama Winning Time: The Rise of the Lakers Dynasty has come under fire from the Lakers’ former general manager Jerry West and star center Kareem Abdul-Jabbar. West, a former player and head coach, was named general manager of the LA Lakers before the 1982–83 NBA season. Under his guidance, the team won five championship rings in the 1980s — the era covered in the HBO series. Abdul-Jabbar was part of those winning teams, and his contributions are regarded as a vital component in the Showtime era of Lakers basketball. According to Deadline, West’s attorneys sent a letter…
These days, what’s old is new again in fashion, and a range of ’90s silhouettes are returning to present-day red carpets. With in-person events officially back on the calendar, celebrities are clearly making up for lost time, placing a range of nostalgic styles on our radar. They’ve recently taken a liking to low-back dresses that dip just far enough to offer a glimpse of butt cleavage, heralding the comeback of another Y2K trend. These backless gowns were a popular choice at the Vanity Fair Oscars party last month, with numerous celebrities embracing the style. Hailey Bieber made a grand entrance…
Authorised Apple service technicians may be able to make Face ID repairs on iPhone XS and newer phones without needing to replace the entire iPhone.As per a report by MacRumors, the tech giant may soon grant Apple Stores and Apple authorised service providers access to a new TrueDepth Camera service part that consists of Face ID and front camera modules. As a result, stores and authorised providers would perform same-unit repairs when a phone suffers from Face ID issues instead of replacing the device.As described by Apple in an internal memo, the move will reduce the carbon footprint of its products…
By Gege Li THIS is a newly discovered colony of gentoo penguins on Andersson Island off the Antarctic Peninsula, photographed by Tomás Munita. The animals and their 75 nests were found by researchers from Stony Brook University in New York during a Greenpeace expedition to the frigid region. The team is surveying, and filming, penguins on archipelagos previously unexplored by foot, to uncover the extent of the effect of climate change on populations of penguins. The birds are considered to be “sentinel species”, in this case alerting us to the impact of a warming world. Tomás Munita / Greenpeace Finding…
In one of the most significant legal shifts in U.S. history, it was leaked Monday night (May 2) that the Supreme Court was planning to overturn the long-standing 1973 Roe v. Wade decision that granted federal constitutional protections for abortion rights and would now put the decisions on the legality of abortions within the hands of the governing bodies of the states instead.As revealed by Politico, an initial draft majority opinion written by Justice Samuel Alito has circulated inside the court, stating that “Roe was egregiously wrong from the start. We hold that Roe and Casey [1992’s Planned Parenthood v.…
Actress Leslie Grace is set to star in the upcoming HBO Max film Batgirl, and in a recent interview with Variety, Grace teased she’s already ready for a sequel.RELATED: HBO Max’s Batgirl Film Wraps Production in Glasgow“We got to see this first one first,” said Grace when asked when a second film might be on the way. “But there’s definitely some talks about what it could be. I’ve seen some of what we’ve shot, obviously in the playback and stuff like that, and it’s insane.”Grace went on to say that she and filmmakers Adil El Arbi and Bilall Fallah have already…
26 Apr 2022 Set off on an adventure to new worlds this week! This selection of new science fiction and fantasy books will surely please! Science Fiction fans should be excited about the latest from bestselling authors Michael Chatfield, David Barnett, W. C. Collier, and more. If Fantasy is what your library needs, you’ll be able to pick up the latest from Marc Secchia, Amber Nicole, T. Kingfisher, and more. Enjoy your new science fiction and fantasy books. Happy reading! Fantasy Science Fiction Related grant scrolls_pure; if (shouldBeFixed && !isFixed) { header.addClass(“sticky”); isFixed = true; } else if (!shouldBeFixed && isFixed) { header.removeClass(“sticky”); isFixed…
We’ll take Ken Jennings for…full-time host of Jeopardy! And we’d wager a bet we’re not alone. Since the great Alex Trebek’s passing in 2020 from pancreatic cancer, the 47-year-old former Jeopardy! champion and consulting producer has become one of the most popular replacements to fill the late icon’s spot, thanks to his smarts, magnetism and endearing dad jokes. Jennings’ current tenure — he’s been sharing hosting duties with The Big Bang Theory alum Mayim Bialik since last September — continues to convince us that he is perfect for the job. Even if he wasn’t sold on the idea when he…